Abstract
Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthesis and SAR of these compounds are described.
MeSH terms
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology
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Hydroquinones / chemical synthesis*
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Hydroquinones / pharmacology
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Benzimidazoles
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Enzyme Inhibitors
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Heterocyclic Compounds
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Hydroquinones
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Receptor Protein-Tyrosine Kinases